Cancer genomics

Genomically Smoldering Multiple Myeloma Is Not a Distinct Entity But a Collection of Monoclonal Gammopathy of Undetermined Significance or Multiple Myeloma

Aktas Samur A, Corre J, Talluri S, …, Szalat R, …, Samur MK

Journal of Clinical Oncology44(4):321-334DOI: Genomically Smoldering Multiple Myeloma Is Not a Distinct Entity But a Collection of Monoclonal Gammopathy of Undetermined Significance or Multiple MyelomaPubMed: Genomically Smoldering Multiple Myeloma Is Not a Distinct Entity But a Collection of Monoclonal Gammopathy of Undetermined Significance or Multiple Myeloma

Genetic Predictors of Mortality in Patients with Multiple Myeloma

Hassan H, Szalat R

The Application of Clinical GeneticsVolume 14:241-254DOI: Genetic Predictors of Mortality in Patients with Multiple MyelomaPubMed: Genetic Predictors of Mortality in Patients with Multiple Myeloma

Genome-Wide Somatic Alterations in Multiple Myeloma Reveal a Superior Outcome Group

Samur MK, Aktas Samur A, Fulciniti M, Szalat R, …, Munshi NC

Journal of Clinical Oncology38(27):3107-3118DOI: Genome-Wide Somatic Alterations in Multiple Myeloma Reveal a Superior Outcome GroupPubMed: Genome-Wide Somatic Alterations in Multiple Myeloma Reveal a Superior Outcome Group

Genomic landscape and chronological reconstruction of driver events in multiple myeloma

Maura F, Bolli N, Angelopoulos N, …, Szalat R, …, Campbell PJ

Nature Communications10(1)DOI: Genomic landscape and chronological reconstruction of driver events in multiple myelomaPubMed: Genomic landscape and chronological reconstruction of driver events in multiple myeloma

A high-risk, Double-Hit, group of newly diagnosed myeloma identified by genomic analysis

Walker BA, Mavrommatis K, Wardell CP, …, Szalat R, …, Morgan G

Leukemia33(1):159-170DOI: A high-risk, Double-Hit, group of newly diagnosed myeloma identified by genomic analysisPubMed: A high-risk, Double-Hit, group of newly diagnosed myeloma identified by genomic analysis

Genomic patterns of progression in smoldering multiple myeloma

Bolli N, Maura F, Minvielle S, …, Szalat R, …, Munshi N

Nature Communications9(1)DOI: Genomic patterns of progression in smoldering multiple myelomaPubMed: Genomic patterns of progression in smoldering multiple myeloma

Identification of novel mutational drivers reveals oncogene dependencies in multiple myeloma

Walker BA, Mavrommatis K, Wardell CP, …, Szalat R, …, Morgan GJ

Blood132(6):587-597DOI: Identification of novel mutational drivers reveals oncogene dependencies in multiple myelomaPubMed: Identification of novel mutational drivers reveals oncogene dependencies in multiple myeloma

Next-Generation Sequencing Informing Therapeutic Decisions and Personalized Approaches

Szalat R, Munshi NC

American Society of Clinical Oncology Educational Booke442-e448DOI: Next-Generation Sequencing Informing Therapeutic Decisions and Personalized ApproachesPubMed: Next-Generation Sequencing Informing Therapeutic Decisions and Personalized Approaches

High Throughput Genomic Analysis Identifies Low-Risk Smoldering Multiple Myeloma

Aktas-Samur A, Fulciniti M, Derebail S, Szalat R, …, Munshi NC

Blood136(Supplement 1):2-2DOI: High Throughput Genomic Analysis Identifies Low-Risk Smoldering Multiple Myeloma

E2 ubiquitin conjugase UBE2T contributes to genome maintenance through homologous recombination in multiple myeloma

Alagpulinsa D, Kumar S, Talluri S, …, Szalat R, …, Munshi N

Clinical Lymphoma Myeloma and Leukemia19(10):e139DOI: E2 ubiquitin conjugase UBE2T contributes to genome maintenance through homologous recombination in multiple myeloma

Genome wide chromatin accessibility profiling identifies chromatin signatures and novel transcription factor dependencies in multiple myeloma

Szalat R, Lawlor M, Fulciniti M, …, Munshi N

Clinical Lymphoma Myeloma and Leukemia19(10):e8-e9DOI: Genome wide chromatin accessibility profiling identifies chromatin signatures and novel transcription factor dependencies in multiple myeloma

Lack of Significant Differences in Somatic Alterations between MGUS, SMM and Symptomatic Multiple Myeloma: A Result from Comprehensive Genomic Profiling Study

Aktas Samur A, Fulciniti M, Szalat R, …, Munshi NC

Blood134(Supplement_1):3089-3089DOI: Lack of Significant Differences in Somatic Alterations between MGUS, SMM and Symptomatic Multiple Myeloma: A Result from Comprehensive Genomic Profiling Study

Recurrent somatic Alterations in the Non-Coding Genome Alter Gene Expression Levels and Correlate With Clinical Outcome

Samur M, Samur A, Szalat R, …, Munshi N

Clinical Lymphoma Myeloma and Leukemia19(10):e12-e13DOI: Recurrent somatic Alterations in the Non-Coding Genome Alter Gene Expression Levels and Correlate With Clinical Outcome

S119 THE ROLE OF RECURRENT SOMATIC ALTERATIONS IN THE NON-CODING GENOME WITH FUNCTIONAL IMPLICATIONS IN MM

Samur M, Szalat R, Aktas Samur A, …, Munshi N

HemaSphere3(S1):11-12DOI: S119 THE ROLE OF RECURRENT SOMATIC ALTERATIONS IN THE NON-CODING GENOME WITH FUNCTIONAL IMPLICATIONS IN MM

The Landscape of Genome Wide Somatic Alterations Identifies a Good-Risk Group in Newly Diagnosed Multiple Myeloma

Samur MK, Aktas Samur A, Han T, …, Szalat R, …, Munshi NC

Blood134(Supplement_1):3055-3055DOI: The Landscape of Genome Wide Somatic Alterations Identifies a Good-Risk Group in Newly Diagnosed Multiple Myeloma

Analysis of mutations and structural variants to redefine the genomic landscape of multiple myeloma and its clinical implications

Bolli N, Maura F, Dawson KJ, Angelopoulos N, Minvielle S, Martincorena I, et al.

Haematologica103(S3):S51-S51

Landscape of Recurrent Mutations in Non-Coding Genome with Functional Implications in Newly-Diagnosed Multiple Myeloma

Samur MK, Chakraborty C, Szalat R, …, Munshi N

Blood132(Supplement 1):190-190DOI: Landscape of Recurrent Mutations in Non-Coding Genome with Functional Implications in Newly-Diagnosed Multiple Myeloma

The genomic landscape of structural variations and complex events in multiple myeloma

Maura F, Dawson KJ, Angelopoulos N, Minvielle S, Martincorena I, et al.

Haematologica103(S3):S14-S14

Integrative Oncogenomic Analysis Combining Whole Genome, Transcriptome and Epigenome Identifies Altered Chromatin Accessibility Landscape in Multiple Myeloma

Szalat R, Samur MK, Ott CJ, Lawlor M, Epstein C, Abraham BJ, Lin CY, et al.

Blood130:328

The genomic landscape of multiple myeloma complex structural variations

Maura F, Bolli N, Dawson KJ, Angelopoulos N, Minvielle S, Martincorena I, et al.

Blood, The Journal of the American Society of Hematology130(Suppl_1):330-330

A targeted sequencing approach in multiple myeloma reveals a complex landscape of genomic lesions that has implications for prognosis

Bolli N, Biancon G, Gimondi S, Li Y, Sathiaseelan V, Maura F, Carniti C, et al.

HAEMATOLOGICA101(Suppl. 1):160-160

Analysis of Mutational Signatures Suggest That Aid Has an Early and Driver Role in Multiple Myeloma

Maura F, Bolli N, Minvielle S, …, Szalat R, …, Munshi N

Blood128(22):116-116DOI: Analysis of Mutational Signatures Suggest That Aid Has an Early and Driver Role in Multiple Myeloma

Global Genomic Analysis of Newly Diagnosed t(4 ;14) Multiple Myeloma Reveals a Specific Mutational Spectrum and Identifies PKD2 As a Potential Therapeutic Target

Song XL, Szalat R, Talbot A, …, Bories JC

Blood128(22):4462-4462DOI: Global Genomic Analysis of Newly Diagnosed t(4 ;14) Multiple Myeloma Reveals a Specific Mutational Spectrum and Identifies PKD2 As a Potential Therapeutic Target

The Complex Landscape of Rearrangements in Smoldering and Symptomatic Multiple Myeloma Revealed By Whole-Genome Sequencing

Szalat R, Bolli N, Maura F, …, Munshi NC

Blood128(22):236-236DOI: The Complex Landscape of Rearrangements in Smoldering and Symptomatic Multiple Myeloma Revealed By Whole-Genome Sequencing

Whole Genome Sequencing of Unique Paired SMM/MGUS Progressing to MM Samples Reveals a Genomic Landscape with Diverse Evolutionary Pattern

Bolli N, Maura F, Minvielle S, …, Szalat R, …, Munshi N

Blood128(22):2088-2088DOI: Whole Genome Sequencing of Unique Paired SMM/MGUS Progressing to MM Samples Reveals a Genomic Landscape with Diverse Evolutionary Pattern