Gene expression and transcriptomics

ID2 Suppresses Multiple Myeloma Cell Proliferation by Repressing the Activity of the Transcription Factor TCF3

Fulciniti M, Yao Y, Perini T, …, Szalat R, …, Munshi NC

Blood Cancer Discovery7(1):129-141DOI: ID2 Suppresses Multiple Myeloma Cell Proliferation by Repressing the Activity of the Transcription Factor TCF3PubMed: ID2 Suppresses Multiple Myeloma Cell Proliferation by Repressing the Activity of the Transcription Factor TCF3

Bone marrow stromal cells induce chromatin remodeling in multiple myeloma cells leading to transcriptional changes

Binder M, Szalat RE, Talluri S, Fulciniti M, Avet-Loiseau H, Parmigiani G, Samur MK, Munshi NC

Nature Communications15(1)DOI: Bone marrow stromal cells induce chromatin remodeling in multiple myeloma cells leading to transcriptional changesPubMed: Bone marrow stromal cells induce chromatin remodeling in multiple myeloma cells leading to transcriptional changes

IgM-MM is predominantly a pre–germinal center disorder and has a distinct genomic and transcriptomic signature from WM

Bazarbachi AH, Avet-Loiseau H, Szalat R, …, Samur MK

Blood138(20):1980-1985DOI: IgM-MM is predominantly a pre–germinal center disorder and has a distinct genomic and transcriptomic signature from WMPubMed: IgM-MM is predominantly a pre–germinal center disorder and has a distinct genomic and transcriptomic signature from WM

Functional profiling of nucleotide Excision repair in breast cancer

Rajkumar-Calkins AS, Szalat R, Dreze M, …, Mouw KW

DNA Repair82:102697DOI: Functional profiling of nucleotide Excision repair in breast cancerPubMed: Functional profiling of nucleotide Excision repair in breast cancer

Genomic patterns of progression in smoldering multiple myeloma

Bolli N, Maura F, Minvielle S, …, Szalat R, …, Munshi N

Nature Communications9(1)DOI: Genomic patterns of progression in smoldering multiple myelomaPubMed: Genomic patterns of progression in smoldering multiple myeloma

Identification of novel mutational drivers reveals oncogene dependencies in multiple myeloma

Walker BA, Mavrommatis K, Wardell CP, …, Szalat R, …, Morgan GJ

Blood132(6):587-597DOI: Identification of novel mutational drivers reveals oncogene dependencies in multiple myelomaPubMed: Identification of novel mutational drivers reveals oncogene dependencies in multiple myeloma

Long intergenic non-coding RNAs have an independent impact on survival in multiple myeloma

Samur MK, Minvielle S, Gulla A, …, Szalat R, …, Munshi NC

Leukemia32(12):2626-2635DOI: Long intergenic non-coding RNAs have an independent impact on survival in multiple myelomaPubMed: Long intergenic non-coding RNAs have an independent impact on survival in multiple myeloma

Non-overlapping Control of Transcriptome by Promoter- and Super-Enhancer-Associated Dependencies in Multiple Myeloma

Fulciniti M, Lin CY, Samur MK, …, Szalat RE, …, Munshi NC

Cell Reports25(13):3693-3705.e6DOI: Non-overlapping Control of Transcriptome by Promoter- and Super-Enhancer-Associated Dependencies in Multiple MyelomaPubMed: Non-overlapping Control of Transcriptome by Promoter- and Super-Enhancer-Associated Dependencies in Multiple Myeloma

Expressed fusion gene landscape and its impact in multiple myeloma

Cleynen A, Szalat R, Samur MK, …, Avet-Loiseau H

Nature Communications8(1)DOI: Expressed fusion gene landscape and its impact in multiple myelomaPubMed: Expressed fusion gene landscape and its impact in multiple myeloma

Functional role and therapeutic targeting of p21-activated kinase 4 in multiple myeloma

Fulciniti M, Martinez-Lopez J, Senapedis W, …, Szalat R, …, Munshi NC

Blood129(16):2233-2245DOI: Functional role and therapeutic targeting of p21-activated kinase 4 in multiple myelomaPubMed: Functional role and therapeutic targeting of p21-activated kinase 4 in multiple myeloma

Gene Expression Profiles in Myeloma: Ready for the Real World?

Szalat R, Avet-Loiseau H, Munshi NC

Clinical Cancer Research22(22):5434-5442DOI: Gene Expression Profiles in Myeloma: Ready for the Real World?PubMed: Gene Expression Profiles in Myeloma: Ready for the Real World?

Genomic heterogeneity in multiple myeloma

Szalat R, Munshi NC

Current Opinion in Genetics & Development30:56-65DOI: Genomic heterogeneity in multiple myelomaPubMed: Genomic heterogeneity in multiple myeloma

Single-cell transcriptomics of AL amyloidosis reveals pathogenic mechanisms, immune interactions and altered clonal and polyclonal plasma cell phenotypes

Smith J, Samur M, Talluri S, …, Szalat R

Blood146(Supplement 1):3923-3923DOI: Single-cell transcriptomics of AL amyloidosis reveals pathogenic mechanisms, immune interactions and altered clonal and polyclonal plasma cell phenotypes

Bone marrow plasma cells and immune microenvironment transcriptomic architecture in AL amyloidosis during daratumumab based therapy

Szalat R, Talluri S, Wong S, Morgan G, Sanchorawala V, Munshi N, et al.

AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS31:S176-S176

P-362 ID2 acts as a novel tumor suppressor in MM by inhibition of TCF3 transcriptional activity

Perini T, Yao Y, Ng JF, …, Szalat R, …, Munshi N

Clinical Lymphoma Myeloma and Leukemia23:S238-S239DOI: P-362 ID2 acts as a novel tumor suppressor in MM by inhibition of TCF3 transcriptional activity

OAB-021: High-risk multiple myeloma due to extramedullary disease-like gene expression induced by bone marrow stromal cells

Binder M, Szalat R, Fulciniti M, Avet-Loiseau H, Parmigiani G, Samur M, Munshi N

Clinical Lymphoma Myeloma and Leukemia22:S13DOI: OAB-021: High-risk multiple myeloma due to extramedullary disease-like gene expression induced by bone marrow stromal cells

Chromatin Remodeling and Associated Changes in Gene Expression Induced By Bone Marrow Stromal Cells Identify Features of High-Risk Multiple Myeloma

Binder M, Szalat RE, Fulciniti M, Parmigiani G, Samur MK, Munshi NC

Blood138(Supplement 1):2672-2672DOI: Chromatin Remodeling and Associated Changes in Gene Expression Induced By Bone Marrow Stromal Cells Identify Features of High-Risk Multiple Myeloma

Transcriptional Deregulation Mediated By ID2-TCF3 Axis Supports MM Cell Growth and Proliferation in the Context of the Bone Marrow Milieu

Yao Y, Perini T, Samur MK, Szalat R, Binder M, Anderson KC, Fulciniti M, Munshi NC

Blood138(Supplement 1):2686-2686DOI: Transcriptional Deregulation Mediated By ID2-TCF3 Axis Supports MM Cell Growth and Proliferation in the Context of the Bone Marrow Milieu

Genomic and Transcriptomic Characterization of IgM Multiple Myeloma Identifies a Pre-Germinal Center Plasma Cell Disorder with Immature B-Cell Transcription-Factor Signature

Bazarbachi AH, Avet-Loiseau H, Hunter ZR, Szalat R, …, Munshi NC

Blood136(Supplement 1):7-8DOI: Genomic and Transcriptomic Characterization of IgM Multiple Myeloma Identifies a Pre-Germinal Center Plasma Cell Disorder with Immature B-Cell Transcription-Factor Signature

Inhibitor of DNA binding 2 (ID2) regulates key transcriptional programs in multiple myeloma

Perini T, Szalat R, Samur M, …, Munshi N

Clinical Lymphoma Myeloma and Leukemia19(10):e98-e99DOI: Inhibitor of DNA binding 2 (ID2) regulates key transcriptional programs in multiple myeloma

Recurrent somatic Alterations in the Non-Coding Genome Alter Gene Expression Levels and Correlate With Clinical Outcome

Samur M, Samur A, Szalat R, …, Munshi N

Clinical Lymphoma Myeloma and Leukemia19(10):e12-e13DOI: Recurrent somatic Alterations in the Non-Coding Genome Alter Gene Expression Levels and Correlate With Clinical Outcome

A NOVEL PREDICTIVE MODEL COMBINING LINCRNAS AND PROTEIN CODING GENES IN MULTIPLE MYELOMA

Samur M, Gulla A, Fulciniti M, Szalat R, Samur AA, Shamas M, et al.

HAEMATOLOGICA102:495-496

Abstract 5719: Long intergenic non-coding RNAs: a new independent risk predictors in multiple myeloma

Samur MK, Gulla A, Fulciniti M, …, Szalat R, …, Munshi N

Cancer Research77(13_Supplement):5719-5719DOI: Abstract 5719: Long intergenic non-coding RNAs: a new independent risk predictors in multiple myeloma

Integrative Oncogenomic Analysis Combining Whole Genome, Transcriptome and Epigenome Identifies Altered Chromatin Accessibility Landscape in Multiple Myeloma

Szalat R, Samur MK, Ott CJ, Lawlor M, Epstein C, Abraham BJ, Lin CY, et al.

Blood130:328

Mapping of the Multiple Myeloma Transcriptional Core Regulatory Circuitry Reveals TCF3 As a Novel Dependency and an Oncogenic Collaborator of MYC

Lin CY, Fulciniti M, Lopez MA, …, Szalat R, …, Munshi N

Blood130(Suppl_1):64-64DOI: Mapping of the Multiple Myeloma Transcriptional Core Regulatory Circuitry Reveals TCF3 As a Novel Dependency and an Oncogenic Collaborator of MYC

A Detailed Alternate Splicing Landscape in Multiple Myeloma with Significant Potential Biological and Clinical Implications

Aktas Samur A, Samur MK, Minvielle S, …, Szalat R, …, Munshi NC

Blood128(22):356-356DOI: A Detailed Alternate Splicing Landscape in Multiple Myeloma with Significant Potential Biological and Clinical Implications

Frequent Igh Fusion Transcripts with Clinical Impact in Multiple Myeloma

Cleynen A, Szalat R, Samur MK, Rashid N, Parmigiani G, Munshi NC, Avet-Loiseau H

Blood124(21):721-721DOI: Frequent Igh Fusion Transcripts with Clinical Impact in Multiple Myeloma